中文名 N-[(4-羥基-1-甲基-7-苯氧基-3-異喹啉基)羰基]甘氨酸
英文名 FG-4592
別名 羅沙司他
洛度司他
羅沙司他光降解雜質(zhì)
HIF脯氨酰羥化酶抑制劑(FG-4592)
N-[(4-羥基-1-甲基-7-苯氧基-3-異喹啉)羰基]甘氨酸
N-[(4-羥基-1-甲基-7-苯氧基-3-異喹啉基)羰基]甘氨酸
甘氨酸, N-[(4-羥基-1-甲基-7-苯氧基-3-異喹啉基)羰基]-
FG4592 N-[(4-羥基-1-甲基-7-苯氧基-3-異喹啉)羰基]甘氨酸
英文別名 FG-4592
FG-4592(ASP1517)
N-[(4-Hydroxy-1-Methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine
N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine
Glycine, N-[(4-hydroxy-1-Methyl-7-phenoxy-3-isoquinolinyl)carbonyl]-
Glycine, N-[(4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]-
2-(4-hydroxy-1-Methyl-7-phenoxyisoquinoline-3-carboxaMido)acetic acid
2-(4-HYDROXY-1-METHYL-7-PHENOXYISOQUINOLINE-3-CARBOXAMIDO)ACETIC ACID
[[(4-Hydroxy-1-Methyl-7-phenoxyisoquinolin-3-yl)carbonyl]aMino]acetic Acid
[[(4-Hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]amino]acetic acid
CAS 808118-40-3
EINECS 813-400-2
化學(xué)式 C19H16N2O5
分子量 352.34
InChI InChI=1S/C19H16N2O5/c1-11-15-9-13(26-12-5-3-2-4-6-12)7-8-14(15)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23)
密度 1.389
熔點(diǎn) 199-215°C
沸點(diǎn) 684.3±55.0 °C(Predicted)
溶解度 Soluble in DMSO (up to at least 25 mg/ml).
酸度系數(shù) 2.46±0.10(Predicted)
存儲(chǔ)條件 -20°C
穩(wěn)定性 Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
外觀 solid
顏色 Off-white or white
體外研究 FG-4592是一種口服缺氧誘導(dǎo)因子(HIF)脯氨酰羥化酶抑制劑。FG-4592穩(wěn)定HIF的活動(dòng),HIF是細(xì)胞內(nèi)轉(zhuǎn)錄因子,導(dǎo)致與紅細(xì)胞相關(guān)基因,包括EPO,和參與鐵代謝相關(guān)酶的激活。
上游原料 4-苯氧基-1,2-苯二甲酸
808118-40-3 - 介紹
FG-4592是一種HIF α脯氨酰羥化酶抑制劑,并能穩(wěn)定HIF-2,同時(shí)誘導(dǎo)EPO產(chǎn)生。